Headache cleveland clinic

Headache cleveland clinic DEFAULT

Cleveland Clinic

The Cleveland Clinic Headache Fellowship accepts 2 fellows/year and provides a comprehensive training program that focuses on the preparation of the trainee to become a skilled headache practitioner. Training includes: adult and child headache medicine. We have a 12 bed infusion room for out patient management of staus migrainosis and medication overuse headache. Procedures: Botulium toxin injections, occipital nerve blocks, and trigger point injections. Staff: 10 adult UCNS certified headache specialists and a child headache specialist. There is one research day/wk.

Fellowship Class of 2022-2023

Fellowship Position 1: Elise Hennessy, MD
Fellowship Position
2: Sudipa Biswas, MD

Fellowship Class of 2021-2022

Fellowship Position 1: Jennifer Chima, MD
Fellowship Position
2: Michael Zatt, DO



Sours: https://americanheadachesociety.org/fellowships/cleveland-clinic/

The Cleveland Clinic Manual of Headache Therapy

  • Diagnosis of Major Secondary Headaches 1, the Basics, Head and Neck Trauma, and Vascular Disorders

    Pages 79-95

    Mays, MaryAnn, MD

    PreviewBuy Chapter 24,95 €

  • Diagnosis of Major Secondary Headaches, Nonvascular Disorders

    Pages 97-112

    Mays, MaryAnn, MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Diagnosis of Headache in Children and Adolescents

    Pages 115-126

    Cleves-Bayon, Catalina, MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Episodic Syndromes that May Be Associated with Migraine, Pediatric Tension-type Headache, Chronic Daily Headache Syndromes in Children and Pediatric Idiopathic Intracranial Hypertension

    Pages 127-142

    Cleves-Bayon, Catalina, MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Acute Treatment of Episodic Migraine

    Pages 145-159

    Kriegler, Jennifer S., MD

    PreviewBuy Chapter 24,95 €

  • Preventive Treatment of Episodic Migraine

    Pages 161-178

    Bamford, Cynthia C., MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Treatment of Trigeminal Autonomic Cephalalgias and Other Primary Headaches

    Pages 179-193

    Stillman, Mark J., MD

    PreviewBuy Chapter 24,95 €

  • Treatment of Medication Overuse Headache

    Pages 197-211

    Tepper, Stewart J., MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Medical Treatment of Refractory Daily Headaches, Including Interdisciplinary Management

    Pages 213-225

    Stillman, Mark J., MD

    PreviewBuy Chapter 24,95 €

  • Psychological Comorbidities, Assessment, and Management of Refractory Daily Headaches

    Pages 227-236

    Krause, Steven J., PhD, M.B.A

    PreviewBuy Chapter 24,95 €

  • Detoxification or Wean Treatment of Opioids and Sedatives in Headache and Pain Disorders

    Pages 237-243

    Kriegler, Jennifer S., MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Treatment of Major Secondary Headaches

    Pages 247-258

    Mays, MaryAnn, MD

    PreviewBuy Chapter 24,95 €

  • Treatment of Pediatric and Adolescent Headaches

    Pages 261-276

    Rothner, A. David, MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Behavioral Treatment of Headaches

    Pages 279-289

    Krause, Steven J., PhDMBA

    PreviewBuy Chapter 24,95 €

  • Treatment of Facial Pain and Neuralgias

    Pages 291-298

    Bamford, Cynthia C., MD (et al.)

    PreviewBuy Chapter 24,95 €

  • Treatment and Consideration of Women’s Issues in Headache

    Pages 299-313

    Kriegler, Jennifer S., MD

    PreviewBuy Chapter 24,95 €

  • Diagnosis and Treatment of Dizziness and Headache

    Pages 315-324

    Cherian, Neil, MD

    PreviewBuy Chapter 24,95 €

  • Nursing Issues in the Diagnosis and Treatment of Migraines

    Pages 325-339

    Zajac, Deborah, RN

    PreviewBuy Chapter 24,95 €

  • Headaches, Traumatic Brain Injury, and Concussion

    Pages 341-352

    Alberts, Jay, PhD (et al.)

    PreviewBuy Chapter 24,95 €

  • Sours: https://www.springer.com/gp/book/9783319040714
    1. Asus tuf b550
    2. Croissant nutrition facts
    3. Pixel perfection party
    4. Animal crossing personalities
    5. Quilling numbers


    In 1988, the International Headache Society first published a detailed classification of headache. This classification has been updated and revised multiple times, most recently in July 2013 with the publication of the International Classification of Headache Disorders, 3rd edition.1 All headaches can be classified as either a primary headache or as a secondary headache, which is defined as a headache that is caused by an underlying disease process or medical condition. Primary headache disorders are the most common. This discussion will focus on the diagnosis and management of the most common primary headaches.


    Primary headache syndromes are divided into 4 groups: migraine, tension-type, trigeminal autonomic cephalalgias and other. Other is defined as headaches not of the other 3 groups that do not have a secondary cause.1 All headaches can be infrequent (episodic) or may become chronic. Chronic headache refers to a headache that occurs on 15 days or more a month. In the case of cluster headache, the most common of the trigeminal autonomic cephalalgias, chronic is defined as the absence of headache for less than 1 week a month for more than 6 months.1

    Primary headaches disorders are not associated with any demonstrable structural abnormality of the brain. The diagnosis of the headache type is based on patient history, headache characteristics, and a normal neurological exam. Laboratory and imaging test results are normal, so in general, expensive studies like imaging are not obtained. During the headache attack, however, patients with cluster and migraine headache may have some abnormal clinical findings. Primary headache disorders typically occur early in life with a decreased incidence of new primary headache disorders after the age of 40 to 50.

    Secondary headaches are usually of recent onset and associated with abnormalities found on clinical examination. Laboratory testing, imaging studies, or both confirm the diagnosis. Recognizing headaches related to an underlying condition or disease is critical not only because treatment of the underlying problem usually eliminates the headache, but because the condition causing the headache may be life-threatening.

    Back to Top


    Primary headaches account for more than 90% of all headache complaints, and of these, episodic tension-type headache is the most common.1 The lifetime prevalence of tension-type headache is 30% to 78% based on various studies.1,2 The mean age at onset is 25 to 30 years with a peak prevalence at 30 to 39 years. The socioeconomic impact of tension- type headache is significant.3

    The prevalence of migraine varies form 12% to 20% of the population and has an estimated worldwide 1-year prevalence of greater than 1 billion.4 Migraine ranks sixth as years lived with a disability worldwide and for individuals under the age of 50, it is the third highest cause of disability.5 There are approximately 28 million migraine sufferers age 12 years and older in the United States with a prevalence of about 18% in women and 6% in males. One in 4 households has at least 1 migraine sufferer. The prevalence of migraine peaks between 25 and 55 years of age.6 Data from the Centers for Disease Control and Prevention reported the prevalence of migraine to be slightly less (8.8%) compared with diabetes (9.3%) and more prevalent than asthma (7.2%) and arthritis (5.5%).7

    Cluster headache is predominant in males with a prevalence of less than 1% percent. A meta-analysis of 16 population-based epidemiologic studies found:

    • lifetime prevalence of 124 per 100,000 (95% confidence interval [CI] 101, 151), or approximately 0.1%
    • 1-year prevalence of 53 per 100,000 (95% CI 26–95)
    • male to female ratio of 4.3 to 1.8

    Back to Top



    The pathophysiology of migraine is a complex process that begins with primary neuronal dysfunction. The dural vascular structures are innervated by neurons arising from the trigeminal nucleus and dorsal portions of the upper cervical roots. These structures project onto second order neurons in the trigeminal cervical complex and trigeminal nucleus caudalis (TNC). Fibers then ascend to the thalamus and sensory cortex. Pain is felt in the head and neck due to convergence of fibers from the trigeminal nerve via the TNC and upper cervical roots. Pain can be modulated by both descending fibers from the hypothalamus, periaqueductal grey, locus coerulus and nucleus raphe magnus onto the TNC and by ascending fibers from the hypothalamus, locus coerulus, and periaqueductal grey (Figure 1).9

    Cortical spreading depression, originally only thought to occur in migraine with aura occurs in all migraines. This is a slow, self-propagating wave of cellular depolarization across the cerebral cortex that is associated with depression of neuronal activity and altered brain metabolism.10 This process also activates neurons in the TNC and causes the inflammatory process in the meningeal vascular structures to begin causing pain and headache. Brain matrix metalloproteinase is upregulated and this alters the permeability of the blood brain barrier.11

    Central sensitization occurs during this process. Neurons become upregulated and sensitized to both nociceptive and non-nociceptive stimuli. This in turn causes peripheral sensitization where pain receptor fields are enlarged causing increased sensitivity to both noxious and non-noxious stimuli. Allodynia and exacerbation of pain by physical activity is thought to be caused by this process.

    Tension-type Headache

    Although poorly understood, input from myofascial trigger points in the pericranial areas appear to be responsible for episodic tension-type headache. With prolonged nociceptive activation of the pericranial myofascia, central pain pathways are activated and may be responsible for conversion to chronic tension-type headache.12

    Cluster Headache

    The pathophysiology of cluster headache is poorly understood, but is believed to be caused by activation of the posterior hypothalamus with secondary activation of the trigeminal autonomic reflex through the trigeminal-hypothalamic pathway.13 Severe, unilateral pain is mediated by activation of the first division of the trigeminal nerve (V1). The autonomic symptoms associated with cluster headache (lacrimation, miosis, sweating) are thought to be due to parasympathetic outflow from the superior salivatory nucleus via the pterygopalatine (sphenopalatine) ganglion.

    Back to Top

    Signs and Symptoms

    Headache disorders can be differentiated by type based on specific characteristics. The International Classification of Headache Disorders (ICHD), 3rd Edition is the standard by which headaches are categorized (Table 1).1

    Table 1: Defining characteristics of headache disorders
    Disorder typeCharacteristics
    MigraineAt least 5 attacks that
    • Last 4-72 hours (untreated or unsuccessfully treated)
    • Has at least 2 of the following 4 features
      • Unilateral location
      • Pulsating quality
      • Moderate or severe pain
      • Aggravation by or causing avoidance of routine physical activity (ie. walking or climbing stairs)
    • Includes 1 of the following
      • nausea or vomiting or both
      • photophobia and phonophobia
    TensionAt least 10 episodes of headache that last 30 minutes to 7 days associated with
    • At least 2 of the following 4 features
      • Bilateral location
      • Pressing or tightening (non-throbbing) quality
      • Mild to moderate intensity
      • Not aggravation by routine activity
    • Both of the following
      • No nausea or vomiting
      • Photophobia or phonophobia (1 not both)
    ClusterAt least 5 attacks with
    • Severe or very severe unilateral, orbital, supraorbital or temporal pain lasting 15-180 minutes (untreated)
    • Either or both of the following
      • At least 1 of these symptoms ipsilateral to the headache: conjunctival injection or lacrimation or both; nasal congestion or rhinorrhea or both; eyelid edema; forehead and facial sweating; sensation of fullness in the ear; miosis or ptosis or both
      • A sense of restlessness or agitation
    • Attack frequency of between 1 every other day and 8 a day for more than half the time the disorder is active


    Migraine is an episodic headache that lasts between 4 to 72 hours and fulfills the criteria established by the ICHD as shown in (Table 1).

    Most patients with migraine do not have an aura, but when an aura occurs, it is defined as migraine with aura. Visual aura is most common and accounts for 90% of aura. This is typically a fortification spectra: zigzag lines that move across the visual field. Many different auras have been described: scintillating scotoma, kaleidoscope vision, pixelated vision, “orbs in the sky” to name a few. These last from 5 to 60 minutes and are followed by the headache. On occasion, these occur without headache. Sensory disturbances are the second most common aura (pins and needles sensation, numbness) usually affecting the face and arm. Language disturbance (aphasia) is unusual as is motor weakness. When motor weakness occurs, it is classified as hemiplegic migraine. When vertigo, ataxia, diplopia or other brain stem symptoms occur, it is classified as migraine with brainstem aura. Other prodromal symptoms such as yawning, irritability, neck pain, food cravings, burst of energy, or fatigue may occur hours to days preceding the migraine.

    Tension-Type Headache

    Tension-type headache is best described as a mild to moderate, featureless headache. The ICHD definition of tension-type headache is presented in (Table 1).

    Cluster Headache

    Cluster headache is the most common of the trigeminal autonomic cephalalgias and has been described as the “suicide” headache due to its severity. These are attacks of severe unilateral pain, occurring in and around the eye or temple and are associated with ipsilateral conjunctival injection, lacrimation, unilateral sweating, ptosis, or miosis (see Table 1 for ICHD definition). Attacks last 15 to 180 minutes, and may occur once every other day to 8 times a day. Patients are restless or agitated, and may pace or rock to try and relieve the pain. Pain often occurs 1.5 to 2 hours after the patient falls asleep, corresponding to the onset of the first REM cycle of sleep. Attacks often occur in patterns: spring and fall, around the time of the equinoxes. This is thought to be related to circadian rhythm. Alcohol is a potent trigger of the headache when a patient is in a cluster headache cycle. It does not trigger an attack outside of a cluster cycle.

    Back to Top

    Approach to Diagnosis

    The steps to headache diagnosis are presented in (Figure 2). The first step is to always exclude a secondary headache. Excluding a secondary headache may require a laboratory evaluation or imaging or both.

    The SNOOP mnemonic is useful to identify secondary headache:

      S: Systemic signs and symptoms
        Fever, chills, weight loss, history of HIV or malignancy

      N: Neurological signs and symptoms
        Primary headache disorders have a normal neurological exam.

      O: Onset
        First and the worst headache of life. Headache that reaches pick intensity within seconds to minutes.

      O: Older age
        New onset of headache in someone after the age of 40. In general, primary headache disorders begin in young people.

      P: Progression of an existing headache disorder
        Change in location, quality, or frequency of the headache. The most common cause of this is medication overuse.14

    Back to Top



    Educating the patient on migraine and its management is crucial for effective treatment. Treatment is usually a combination of general preventative measures, prophylactic treatment, and abortive treatment (Figure 3).

    General preventative measures include maintaining a headache diary to identify and avoid triggers, limiting use of acute treatments (over-the-counter medications, triptans, etc.) to no more than 2 days per week or 10 days per month to prevent medication overuse headache (rebound headache), following a regular schedule (including weekends and holidays), not skipping meals, eating a balanced diet, getting 8 hours of sleep nightly, minimizing stress, exercising 30 minutes per day, keeping hydrated and drinking 6 to 8 glasses of water daily.

    Goals for abortive treatment of acute migraine were published in 2000 by the US Headache Consortium and include

    • Rapid onset of treatment that works consistently without recurrence;
    • Restoration of normal function with reduced disability;
    • Minimizing use of rescue medication;
    • Optimizing self–care so that there is a reduction in healthcare utilization;
    • Low cost;
    • Minimal adverse effects.15

    Always treat early in the attack before the headache progresses in severity. Whenever possible use migraine-specific medications such as triptans or dihydroergotamine. Contraindications are uncontrolled hypertension, cardiovascular and cerebrovascular disease. Use a formulation based on migraine characteristics: nasal spray or subcutaneous formulation in someone with rapid onset headache or who has nausea and vomiting from the onset. Nonsteroidal anti-inflammatory drugs (NSAIDS) are useful alternatives when triptans are contraindicated. Avoid opioids and butalbital containing compounds since these are not only addictive, but rapidly cause medication overuse headache (MOH). Do not use abortive medications more than 10 days per month to avoid MOH.

    The following are the currently available triptan formulations.16

    • Sumatriptan (Imitrex): 25, 50, 100 mg by mouth (usual dose 50 or 100 mg), 10, 20 mg (20 usual dose) nasal spray, 4, 6 mg subcutaneous (6 mg usual dose)
    • Zolmitriptan (Zomig): 2.5, 5 mg by mouth, once daily, nasal spray
    • Rizatriptan (Maxalt): 5, 10 mg by mouth, once daily (usual dose 10 mg, unless patient is on propranolol, then decrease to 5 mg)
    • Almotriptan (Axert): 6.5, 12.5 mg by mouth (usual dose 12.5 mg)
    • Eletriptan (Relpax): 20, 40 mg by mouth (usual dose 40 mg)
    • Naratriptan (Amerge): by mouth 1, 2.5 mg (usual dose 2.5 mg)
    • Frovatriptan (Frova): by mouth 2.5 mg PO
    • Sumatriptan 85 mg + naproxen sodium 500 mg (Treximet): by mouth

    Back to Top

    Preventive Medications

    There are several reasons to consider daily medication to prevent migraines should. Prophylaxis should always be used when migraine significantly interferes with an individual’s daily routine, despite acute treatment or if the frequency of attacks are more than 1 a week. Certain uncommon migraine conditions, such as hemiplegic migraine, always require preventative treatment.

    A clinic-based study on the development of chronic daily headache (CDH) over the course of 1 year showed that the risk of developing chronic daily headache increased dramatically with the frequency of migraine. The odds ratios for developing CHD was 6.2 (95% confidence interval [CI] 1.7–26.6) for patients with headache 10 to 14 days a month compared with patients with headache 0 to 4 days per month.17

    The 2000 US Headache Consortium suggested daily prevention when migraine significantly interferes with the patient’s daily routine despite acute treatment, ≥ 2 long, significantly disabling attacks/month, infrequent attacks but producing profound disability, and failure, contraindication, or troublesome side effects from acute medication.15

    General Principles for Starting Preventative Treatment

    Always start with a low dose of medication and increase gradually to minimize side effects. An adequate trial duration of therapy is 6 to 8 weeks at the target dose. Manage patient expectations because there is no quick fix and the goal of prevention is a 50% reduction in intensity or frequency or both. Encourage patients to use a calendar to accurately assess treatment benefits and evaluate efficacy. Taper the medication and discontinue it if headaches are well controlled. Instruct women about the need for birth control as many of migraine drugs are contraindicated in pregnancy. Always consider a patient’s comorbid and coexistent illnesses and disorders. One medication may be able to be used to treat concurrent disorders (Table 2).

    Table 2: Migraine Preventive Treatment and Coexisting Conditions
    DrugContraindicationsCoexisting conditions
    ValproateLiver disease, bleeding disordersEpilepsy, mania, anxiety
    TopiramateKidney stonesEpilepsy, mania, obesity
    Tricyclic antidepressants (amitriptyline)Mania, urinary retention, heart blockOther pain disorders, fibromyalgia, depression, anxiety, insomnia
    Serotonin and norepinephrine reuptake inhibitors (venlafaxine)ManiaDepression, fibromyalgia
    Beta blockersAsthma, depression, Raynaud’s diabetes, congestive heart failureHypertension, angina
    Calcium channel blockersConstipation, hypotensionMigraine with aura, hypertension, angina
    Natural supplementsPatient preference


    Selection of a migraine preventative drug for use should be based on clinical evidence. The American Academy of Neurology recommends evidence-based treatment for episodic migraine.18,19

    Level A

    • Anticonvulsants: divalproex sodiuma, sodium valproate, topiramatea
    • Beta blockers: propranolola, metoprolol, timolola
    • Angiotensin II receptor blockers: candesartan
    • Calcitonin gene-related peptide receptor antagonist monoclonal antibody: erenumab-aooea
    • Natural Supplements: petasites (use with caution due to liver toxicity)

    Level B

    • Antidepressants: amitriptyline, venlafaxine
    • Beta blockers: atenolol, nadolol

    aFDA approved.

    The only medication specifically developed for the treatment of migraine is erenumab-aooe (Aimovig). Currently, there are 3 additional drugs targeting the calcitonin gene-related peptide receptor in phase 3 clinical trials (fremanezumab, NCT03308968; galcanezumab NCT03559257; eptinezumab).

    Tension-type Headache

    Management of tension-type headache begins by identifying and managing possible triggers and comorbid conditions.

    Acute Therapy

    Analgesics such as acetaminophen and NSAIDs are usually considered to be first-line treatment for acute tension headache episodes. Combination analgesics, which combine caffeine with first-line drugs should be used as an option if analgesics alone are inadequate. Avoid use of barbiturate and opioid medications due to abuse potential and risk of MOH. Always limit use of medication to no more than 2 days a week or 10 days a month to avoid MOH. If tension headache occurs more frequently, prophylactic medication or alternative management strategies such as cognitive behavioral therapy, physical therapy, or acupuncture may be employed.

    Preventative Therapy

    In general starting with a low dose of medicine and slowly titrating to an effective dose is the best strategy for success. Always use the smallest dose of medication necessary to prevent the headache. Tricyclic antidepressants, such as amitriptyline or nortriptyline, are first-line therapy. Serotonin and norepinephrine reuptake inhibitors, such as venlafaxine, may be used as an alternative therapy.

    Cluster Headache

    The main goals for management of cluster headache are to resolve the attack quickly and induce rapid remission of the episode. Management is always done concurrently with both abortive and preventative medications. Rapid control of a cluster headache cycle with a bridge between abortive and preventative medications can be done in a number of ways.

    Occipital nerve blocks involve the injection of a steroid with local anesthetic into the occipital nerves. Greater occipital nerve block is done ipsilateral to the attack using either betamethasone or triamcinolone with bupivacaine 0.5%. A study by Ambrosini et al,20 found 85% (11/13) of patients with cluster headache injected with lidocaine + betamethasone were attack free at 1 week compared with patients injected with lidocaine + saline (n = 10) reporting no freedom from pain. At 4 weeks, 61% (3/13) of patients given lidocaine + betamethasone had sustained headache relief compared with no relief for patients in the lidocaine + saline group.

    High-dose systemic steroids can be given over a course of 10 days to 2 weeks. Either prednisone 60 mg to 80 mg or dexamethasone should be used. A Medrol dose pack does not provide a high enough dose or a long enough duration to be of benefit.

    Dihydroergotamine using a modified Raskin protocol21 can be done on an outpatient basis. The patient can be taught how to give a self-injection or the use of nasal spray to administer 1 mg every 8 hours for 3 to 5 days.

    Abortive therapy for cluster headache includes high-flow oxygen (10 to 15 L/min) via rebreather mask for 15 minutes, subcutaneous dihydroergotamine or sumatriptan, or zolmitriptan 5 mg nasal spray. The oral agents work too slowly to be of benefit to abort a cluster headache.

    Preventive treatment for cluster headache is with verapamil 80 mg 3 times daily to 160 mg 3 times daily. Higher doses may be necessary and an electrocardiogram should be done prior to dose escalation above 240 mg per day because of QTC prolongation. The addition of valproate or topiramate to verapamil is sometimes necessary. For chronic cluster headache, lithium is also used. Thyroid function should be monitored for patients taking lithium.

    Back to Top


    The important components of headache management include:

    • Accurate diagnosis
    • Patient education
    • Nonpharmacotherapy, including trigger management, lifestyle modification (diet and exercise), and behavioral therapy
    • Avoid overuse of acute medications: limit to no more than 2 days a week or 10 days a month to prevent medication overuse headache
    • Use of both prophylactic and abortive medications
    • Headache diary, disability or the migraine-specific quality of life questionnaire to monitor response to treatment.

    Back to Top


      1. Headache Classification Committee of the International Headache Society. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 2013; 33(9): 629–808.
      2. Bendtsen L, Jensen R. Tension-type headache: the most common, but also the most neglected headache disorder. Curr Opin Neurol 2006; 19(3):305–309.
      3. Schwartz BS, Stewart WF, Simon D, Lipton RB. Epidemiology of tension-type headache. JAMA 1998; 279(5):381–383.
      4. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390(10100):1211–1259.
      5. Agosti R. Migraine burden of disease: from the patient’s experience to a socio-economic view. Headache 2018; 58(suppl 1):17–32.
      6. Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001; 41(7):646–657.
      7. Hayek S, Ifrah A, Enav T, Shohat T. Prevalence, Correlates, and Time Trends of Multiple Chronic Conditions Among Israeli Adults: Estimates From the Israeli National Health Interview Survey, 2014–2015. Prev Chronic Dis 2017;14:170038. DOI: http://dx.doi.org/10.5888/pcd14.170038
      8. Fischera M, Marziniak M, Gralow I, Evers S. The incidence and prevalence of cluster headache: a meta-analysis of population-based studies. Cephalalgia 2008; 28(6):614–618.
      9. Reprinted by permission from Springer Nature. Goadsby PJ. Can we develop neutrally acting drugs for the treatment of migraine? Nature Reviews Drug Discover 2005; 4(9):741–750. Copyright 2005
      10. Charles A. Advances in the basic and clinical science of migraine. Ann Neurol 2009 ; 65(5):491–498.
      11. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004; 113(10):1447–1455.
      12. Bendtsen L. Central sensitization in tension-type headache—possible pathophysiological mechanisms. Cephalalgia 2000; 20(5):486–508.
      13. May A. Cluster headache: pathogenesis, diagnosis, and management. Lancet 2005; 366(9488):843–855.
      14. Martin VT. Simplifying the diagnosis of migraine headache. Adv Stud Med 2004; 4(4):200–207.
      15. Silberstein SD; for the US Headache Consortium. Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000; 55:754–763.
      16. [email protected]: FDA Approved Drug Products. U.S. Food & Drug Administration website. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm. Accessed September 18, 2018.
      17. Katsarava Z, Schneeweiss S, Kurth T, et al. Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology 2004; 62(5)788–790.
      18. Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology 2012; 78(17):1337–1345.
      19. Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology 2012; 78(17):1346–1353.
      20. Ambrosini A, Vandenheede M, Rossi P, et al. Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain 2005; 118(1-2):92–96.
      21. Evans RW. An update on the management of chronic migraine. Pract Neurol 2013; Nov-Dec:27–32.

    Back to Top


    Sours: https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/neurology/headache-syndromes/
    Living With Headaches and Migraines with Dr. Emad Estemalik

    Never Drink This With Your Headache Medication, Cleveland Clinic Expert Says

    If you've been feeling like it's the season for headaches, thousands of others can relate to what you're experiencing right now. From allergy-related sinus pressure to migraine symptoms that often come thanks to infection from COVID-19 (specifically Delta), it might seem like just about everybody knows someone who's been suffering from a headache.

    Whatever you're taking to combat your symptoms, a Cleveland Clinic headache specialist has advised you not to consume one thing in particular. Keep reading to find out what you should avoid when a nasty headache strikes. Also, don't miss this news that Diet Soda Is Even Worse for You Than We Thought.

    young woman, who is sitting on a sofa with her eyes closed, touching her head while suffering from a migraine.

    The Cleveland Clinic's blog recently shared advice from Emad Estemalik, M.D., a psychiatrist who is board-certified by the American Board of Psychiatry and Neurology and Headache Medicine.

    Estemalik noted that the headaches many individuals are currently experiencing—especially headaches related to COVID-19—are rather unprecedented given their severity, duration, and the lack of explanation for how COVID-19 is causing them.

    Sign up for the Eat This, Not That! newsletter.

    Neurology Consultation Woman

    The blog suggests that brain scans of COVID patients who are struggling with headaches seem to suggest that many patients' neurological activity is normal.

    To add to the puzzle, Estemalik explained that even after a patient recovers, they can experience "a new onset headache that doesn't remit . . . or pain that gets worse from time to time."

    Overall, Estemalik said: "This tends to be a very, very challenging headache to treat or manage."

    RELATED: I'm a Virus Expert and Here's a Sure Sign You've Had Delta

    Closeup of a young brunette getting some aspirins from a bottle at home.

    Estemalik said doctors are working hard to address patients' symptoms, taking an "interdisciplinary approach." This might include prescriptions or over-the-counter medications, along with holistic recommendations such as diet changes or extra rest.

    The headache expert suggested that if you are taking over-the-counter headache medicine, that's not advisable for more than a week. Also, it's important not to take more than the indicated dosage of medicine, as that "may trigger a rebound headache," Estemalik says.

    One final tip? Avoid overdoing it on caffeine. The Cleveland Clinic said that this may also induce the return of headache symptoms, or worsening of the symptoms you're already feeling.

    RELATED: These 9 Fruits May Trigger Instant Migraines, New Study Says

    Certain drinks, especially those that are caffeinated, can cause other issues when taken with your medication. Learn more by reading One Major Side Effect of Taking Your Medication With Coffee, New Study Says.

    Get more of the latest food and wellness news here:

    Krissy Gasbarre

    Krissy is a senior news editor at <em>Eat This, Not That!</em>, managing morning and weekend news related to nutrition, wellness, restaurants and groceries (with a focus on beverages), and more. Read more

    Sours: https://www.eatthis.com/news-caffeine-headache/

    Clinic headache cleveland

    Water. - The old woman croaked. - Well, no, bitch. Water must be earned. - How.

    Migraines 101: Causes and Treatments

    The convulsions of orgasm shook her body, the vibrator fell to the floor, and a stream of urine gushed from the urethra, splattering the wall opposite. From the bed. - Stand before the Lady, creature.

    Now discussing:

    We will be at your place until 6 pm. Okay. - hung up the phone. - Maybe we should not.

    3837 3838 3839 3840 3841